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1.1.1.145: 3beta-hydroxy-DELTA5-steroid dehydrogenase

This is an abbreviated version!
For detailed information about 3beta-hydroxy-DELTA5-steroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.145

Reaction

a 3beta-hydroxy-DELTA5-steroid
+
NAD+
=
a 3-oxo-DELTA5-steroid
 +
NADH
 +
H+

Synonyms

3 beta- and steroid deltaisomerase 1, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-delta(5)-steroid dehydrogenase, 3-beta-hydroxysteroid dehydrogenase, 3-beta-hydroxysteroid dehydrogenase type-2, 3beta hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-HSD type II, 3beta-HSD1, 3beta-HSD2, 3beta-HSD22, 3beta-HSDH, 3beta-HSD_1, 3beta-hydroxy steroid dehydrogenase/5-ene-4-ene isomerase, 3beta-hydroxy steroid dehydrogenase/isomerase, 3beta-hydroxy-5-ene steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid oxidoreductase, 3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase, 3beta-hydroxy-DELTA5-C27-steroid oxidoreductase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase 1, 3beta-hydroxysteroid dehydrogenase 2, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase type 2, 3beta-hydroxysteroid dehydrogenase type 2 and, 3beta-hydroxysteroid dehydrogenase type II, 3beta-hydroxysteroid dehydrogenase type1, 3beta-hydroxysteroid dehydrogenase/3-ketosteroid reductase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELAT4 isomerase type 2, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase type II, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase type 1, 3beta-hydroxysteroid dehydrogenase/steroid DELTA5,4-isomerase, 3betaHSD, 3betaHSD1, 3betaHSD2, 5-ene-3-beta-hydroxysteroid dehydrogenase, 5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase, dehydrogenase, 3beta-hydroxy-DELTA5-steroid, DELTA5-3beta-hydroxysteroid dehydrogenase, DHRS4, HSD2, HSD3B, HSD3B1, HSD3B2, Hsd3b6, HSDB1, HSDH, More, progesterone reductase, Sl3betaHSD1, Solyc01g73640, steroid-DELTA5-3beta-ol dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase/isomerase, type 2 3beta-hydroxysteroid dehydrogenase, type 2 3beta-hydroxysteroid dehydrogenase/isomerase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase

Reference

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Reference on EC 1.1.1.145 - 3beta-hydroxy-DELTA5-steroid dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ford, H.C.; Engel, L.L.
Purification and properties of the DELTA5-3-beta-hydroxysteroid dehydrogenase-isomerase system of sheep adrenal cortical microsomes
J. Biol. Chem.
249
1363-1368
1974
Ovis aries
Manually annotated by BRENDA team
Simard, J.; Melner, M.H.; Breton, N.; Low, K.G.; Zhao, H.F.; Periman, L.M.; Labrie, F.
Characterization of macaque 3beta-hydroxy-5-ene steroid dehydrogenase/DELTA5-DELTA4-isomerase: structure and expression in steroidogenic and peripheral tissues in primate
Mol. Cell. Endocrinol.
75
101-110
1991
Macaca mulatta
Manually annotated by BRENDA team
Hiwatashi, A.; Hamamoto, I.; Ichikawa, Y.
Purification and kinetic properties of 3beta-hydroxysteroid dehydrogenase from bovine adrenocortical microsomes
J. Biochem.
98
1519-1526
1985
Bos taurus
Manually annotated by BRENDA team
Shikita, M.; Talalay, P.
Preparation of highly purified 3alpha- and 3beta-hydroxysteroid dehydrogenases from Pseudomonas sp
Anal. Biochem.
95
286-292
1979
Pseudomonas sp., Pseudomonas sp. TB
Manually annotated by BRENDA team
Thomas, J.L.; Strickler, R.C.; Myers, R.P.; Covey, D.F
Affinity labeling of human placental 3beta-hydroxy-DELTA5-steroid dehydrogenase and steroid delta-isomerase: evidence for bifunctional catalysis by a different conformation of the same protein for each enzyme activity
Biochemistry
31
5522-5527
1992
Homo sapiens
Manually annotated by BRENDA team
Rabe, T.; Brandstetter, K.; Kellermann, J.; Runnebaum, B.
Partial characterization of placental 3beta-hydroxysteroid dehydrogenase (EC 1.1.1.145), delta 4-5isomerase (EC 5.3.3.1) in human term placental mitochondria
J. Steroid Biochem.
17
427-433
1982
Homo sapiens
Manually annotated by BRENDA team
Armstrong, D.G.
Properties of 5-ene-3beta-hydroxysteroid dehydrogenase in granulosa tissue from the domestic fowl (Gallus domesticus)
J. Steroid Biochem.
17
225-230
1982
Gallus gallus
Manually annotated by BRENDA team
Vincent, M.; Gallay, J.; de Paillerets, C.; Alfsen, A.; Biellmann, J.F.
Role of thiol group(s) in the enzymatic activity of the membrane-bound delta5-3beta-hydroxysteroid dehydrogenase from bovine adrenal cortex microsomes
Biochim. Biophys. Acta
525
1-8
1978
Bos taurus
Manually annotated by BRENDA team
Cheatum, S.G.; Warren, J.C.
Purification and properties of 3-beta-hydroxysteroid dehydrogenase and delta-5-3-ketosteroid isomerase from bovine corpora lutea
Biochim. Biophys. Acta
122
1-13
1966
Bos taurus
Manually annotated by BRENDA team
Koritz, S.B.
The conversion of pregnenolone to progesterone by small particles from rat adrenal
Biochemistry
3
1098-1102
1964
Rattus norvegicus
Manually annotated by BRENDA team
Ishii-Ohba, H.; Inano, H.; Bunichi, T.
Testicular and adrenal 3beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase
J. Steroid Biochem.
27
775-779
1987
Rattus norvegicus
Manually annotated by BRENDA team
Ishii-Ohba, H.; Inano, H.; Tamaoki, B.
Purification and properties of testicular 3beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase
J. Steroid Biochem.
25
555-560
1986
Rattus norvegicus
Manually annotated by BRENDA team
Spona, J.
Differences in inhibition by various steroids of rat testis and Pseudomonas testosteroni DELTA5-3beta-hydroxysteroid dehydrogenase
Endocrinol. Exp.
17
107-118
1983
Comamonas testosteroni, Rattus norvegicus
Manually annotated by BRENDA team
Kerenyi, G.; Szentirmai, A.; Natonek, M.
Properties of delta5-3beta-hydroxysteroid oxidoreductase isolated from Streptomyces griseocarneus
Acta Microbiol. Acad. Sci. Hung.
22
487-496
1975
Streptomyces griseocarneus
Manually annotated by BRENDA team
Pozzi, A.G.; Canosa, L.F.; Calvo, J.C.; Ceballos, N.R.
Kinetic properties of microsomal 3beta hydroxysteroid dehydrogenase-isomerase from the testis of Bufo arenarum H
J. Steroid Biochem. Mol. Biol.
73
257-264
2000
Rhinella arenarum
Manually annotated by BRENDA team
Clarke, T.R.; Bain, P.A.; Sha, L.; Payne, A.H.
Enzyme characteristics of two distinct forms of mouse 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase complementary deoxyribonucleic acids expressed in COS-1 cells
Endocrinology
132
1971-1976
1993
Mus musculus
Manually annotated by BRENDA team
Abbaszade, I.G.; Arensburg, J.; Park, C.H.; Kasa-Vubu, J.Z.; Orly, J.; Payne, A.H.
Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase isoform, 3beta-HSD VI, expressed during early pregnancy
Endocrinology
138
1392-1399
1997
Mus musculus
Manually annotated by BRENDA team
Huang, Y.W.; Lu, M.L.; Qi, H.; Lin, S.X.
Membrane-bound human 3beta-hydroxysteroid dehydrogenase: overexpression with his-tag using a baculvirus system and single-step purification
Protein Expr. Purif.
18
169-174
2000
Homo sapiens
Manually annotated by BRENDA team
Thomas, J.L.; Mason, J.I.; Blanco, G.; Veisaga, M.L.
The engineered, cytosolic form of human type I 3beta-hydroxysteroid dehydrogenase/isomerase: purification, characterization and crystallization
J. Mol. Endocrinol.
27
77-83
2001
Homo sapiens
Manually annotated by BRENDA team
Thomas, J.L.; Evans, B.W.; Blanco, G.; Mason, J.I.; Strickler, R.C.
Creation of a fully active, cytosolic form of human type I 3beta-hydroxysteroid dehydrogenase/isomerase by the deletion of a membrane-spanning domain
J. Mol. Endocrinol.
23
231-239
1999
Homo sapiens
Manually annotated by BRENDA team
Riley, S.C.; Dupont, E.; Walton, J.C.; Luu-The, V.; Labrie, F.; Pelletier, G.; Challis, J.R.
Immunohistochemical localization of 3beta-hydroxy-5-ene-steroid dehydrogenase/DELTA5-DELTA4 isomerase in human placenta and fetal membranes throughout gestation
J. Clin. Endocrinol.
75
956-961
1992
Homo sapiens
Manually annotated by BRENDA team
Suzuki, T.; Sasana, H.; Andersson, S.; Mason, J.I.
3beta-Hydroxysteroid dehydrogenase/DELTA5---4-isomerase activity associated with the human 17beta-hydroxysteroid dehydrogenase type 2 isoform
J. Clin. Endocrinol.
85
3669-3672
2000
Homo sapiens
Manually annotated by BRENDA team
Wong, C.K.; Keung, W.M.
Bovine adrenal 3beta-hydroxysteroid dehydrogenase (E.C. 1.1.1.145)/5-ene-4-ene isomerase (E.C. 5.3.3.1): characterization and its inhibition by isoflavones
J. Steroid Biochem. Mol. Biol.
71
191-202
1999
Bos taurus, Cricetinae
Manually annotated by BRENDA team
Cherradi, N.; Defaye, G.; Chambaz, E.M.
Characterization of the 3beta-hydroxysteroid dehydrogenase activity associated with bovine adrenocortical mitochondria
Endocrinology
134
1358-1364
1994
Bos taurus
Manually annotated by BRENDA team
Furster, C.; Zhang, J.; Toll, A.
Purification of a 3beta-hydroxy-D5-C27-steroid dehydrogenase from pig liver microsomes active in major and alternative pathways of bile acid biosynthesis
J. Biol. Chem.
271
20903-20907
1996
Sus scrofa
Manually annotated by BRENDA team
Hebert, P.; Cooke, G.M.
Kinetic evidence for separate 3beta-hydroxysteroid dehydrogenase-isomerases in androgen and 16-androstene biosynthetic pathways in the pig testis
J. Steroid Biochem. Mol. Biol.
42
901-910
1992
Sus scrofa
Manually annotated by BRENDA team
Nakajin, S.; Ishii, A.; Shinoda, M.
Purification and characterization of 5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase from mature pig testicular cytosol
Biol. Pharm. Bull.
17
1155-1160
1994
Sus scrofa
Manually annotated by BRENDA team
Labrie, F.; Simard, J.; Luu-The, V.; Pelletier, G.; Belanger, A.; Lachance, Y.; Zhao, H.F.; Labrie, C.; Breton, N.; de Launoit, Y.; et al.
Structure and tissue-specific expression of 3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues
J. Steroid Biochem. Mol. Biol.
41
421-435
1992
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Lorence, M.C.; Naville, D.; Graham-Lorence, S.E.; Mack, S.O.; Murry, B.A.; Trant, J.M.; Mason, J.I.
3beta-Hydroxysteroid dehydrogenase/DELTA 5-4-isomerase expression in rat and characterization of the testis isoform
Mol. Cell. Endocrinol.
80
21-31
1991
Rattus norvegicus
Manually annotated by BRENDA team
Sakai, N.; Tanaka, M.; Takahashi, M.; Fukada, S.; Mason, J.I.; Nagahama, Y.
Ovarian 3beta-hydroxysteroid dehydrogenase/DELTA5-4-isomerase of rainbow trout: its cDNA cloning and properties of the enzyme expressed in a mammalian cell
FEBS Lett.
350
309-313
1994
Oncorhynchus mykiss
Manually annotated by BRENDA team
Perry, J.E.; Ishii-Ohba, H.; Stalvey, J.R.
Subcellular distribution of 3beta-hydroxysteroid dehydrogenase-isomerase in bovine and murine adrenocortical tissue: species differences in the localization of activity and immunoreactivity
Steroids
56
329-336
1991
Bos taurus, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Rogerson, F.M.; LeHoux, J.G.; Mason, J.I.
Expression and characterization of isoforms of 3beta-hydroxysteroid dehydrogenase/delta 5->4-isomerase in the hamster
J. Steroid Biochem. Mol. Biol.
55
481-487
1995
Cricetinae
Manually annotated by BRENDA team
Nash, W.E.; Mercer, R.W.; Blanco, G.; Strickler, R.C.; Mason, J.I.; Thomas, J.L.
Over-expression of human type I (placental) 3beta-hydroxy-5-ene-steroid dehydrogenase/isomerase in insect cells infected with recombinant baculovirus
J. Steroid Biochem. Mol. Biol.
50
235-240
1994
Homo sapiens
Manually annotated by BRENDA team
Finsterbusch, A.; Lindemann, P.; Grimm, R.; Eckerskorn, C.; Luckner, M.
DELTA5-3beta-Hydroxysteroid dehydrogenase from Digitalis lanata Ehrh. - a multifunctional enzyme in steroid metabolism?
Planta
209
478-486
1999
Digitalis lanata, Digitalis lanata L.
Manually annotated by BRENDA team
Thomas, J.L.; Mason, J.I.; Brandt, S.; Norris, W.
Differences in substrate and inhibitor kinetics of human type 1 and type 2 3beta-hydroxysteroid dehydrogenase are explained by the type 1 mutant, H156Y
Endocr. Res.
28
471-475
2002
Homo sapiens
Manually annotated by BRENDA team
Thomas, J.L.; Mason, J.I.; Brandt, S.; Spencer, B.R., Jr.; Norris, W.
Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity
J. Biol. Chem.
277
42795-42801
2002
Homo sapiens, Homo sapiens (P14060), Homo sapiens (P26439)
Manually annotated by BRENDA team
Thomas, J.L.; Duax, W.L.; Addlagatta, A.; Scaccia, L.A.; Frizzell, K.A.; Carloni, S.B.
Serine 124 completes the Tyr, Lys and Ser triad responsible for the catalysis of human type 1 3beta-hydroxysteroid dehydrogenase
J. Mol. Endocrinol.
33
253-261
2004
Homo sapiens
Manually annotated by BRENDA team
Coirini, H.; Gouezou, M.; Delespierre, B.; Liere, P.; Pianos, A.; Eychenne, B.; Schumacher, M.; Guennoun, R.
Characterization and regulation of the 3beta-hydroxysteroid dehydrogenase isomerase enzyme in the rat sciatic nerve
J. Neurochem.
84
119-126
2003
Rattus norvegicus
Manually annotated by BRENDA team
Coirini, H.; Gouezou, M.; Delespierre, B.; Schumacher, M.; Guennoun, R.
3 beta-hydroxysteroid dehydrogenase isomerase (3beta-HSD) activity in the rat sciatic nerve: kinetic analysis and regulation by steroids
J. Steroid Biochem. Mol. Biol.
85
89-94
2003
Rattus norvegicus
Manually annotated by BRENDA team
McVey, M.J.; Cooke, G.M.
Inhibition of rat testis microsomal 3b-hydroxysteroid dehydrogenase activity by tributyltin
J. Steroid Biochem. Mol. Biol.
86
99-105
2003
Rattus norvegicus
Manually annotated by BRENDA team
Ohno, S.; Matsumoto, N.; Watanabe, M.; Nakajin, S.
Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II
J. Steroid Biochem. Mol. Biol.
88
175-182
2004
Homo sapiens
Manually annotated by BRENDA team
Thomas, J.L.; Duax, W.L.; Addlagatta, A.; Kacsoh, B.; Brandt, S.E.; Norris, W.B.
Structure/function aspects of human 3beta-hydroxysteroid dehydrogenase
Mol. Cell. Endocrinol.
215
73-82
2004
Homo sapiens
Manually annotated by BRENDA team
Qujeq, D.
Development of a quantitative assay method for 3 beta-hydroxy-DELTA 5-steroid dehydrogenase in the rat testis
Steroids
67
1071-1077
2002
Rattus norvegicus
Manually annotated by BRENDA team
Thomas, J.L.; Boswell, E.L.; Scaccia, L.A.; Pletnev, V.; Umland, T.C.
Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3b-HSD1) for substrates, coenzymes, and inhibitors relative to human 3b-HSD2
J. Biol. Chem.
280
21321-21328
2005
Homo sapiens (P14060), Homo sapiens (P26439), Homo sapiens
Manually annotated by BRENDA team
Sun, W.; Huang, Y.; Zhao, Z.; Gui, J.; Zhang, Q.
Characterization of the Rana grylio virus 3beta-hydroxysteroid dehydrogenase and its novel role in suppressing virus-induced cytopathic effect
Biochem. Biophys. Res. Commun.
351
44-50
2006
Rana grylio iridovirus (Q0G9Z6), Rana grylio iridovirus 9506 (Q0G9Z6)
Manually annotated by BRENDA team
Nakamura, Y.; Suzuki, T.; Inoue, T.; Tazawa, C.; Moriya, T.; Saito, H.; Ishibashi, T.; Takahashi, S.; Yamada, S.; Sasano, H.
3beta-hydroxysteroid dehydrogenase in human aorta
Endocr. J.
52
111-115
2005
Homo sapiens
Manually annotated by BRENDA team
Martin, L.J.; Tremblay, J.J.
The human 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in steroidogenic cells
Endocrinology
146
861-869
2005
Homo sapiens
Manually annotated by BRENDA team
Nicolau-Solano, S.I.; McGivan, J.D.; Whittington, F.M.; Nieuwhof, G.J.; Wood, J.D.; Doran, O.
Relationship between the expression of hepatic but not testicular 3beta-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue
J. Anim. Sci.
84
2809-2817
2006
Sus scrofa (Q9N119)
Manually annotated by BRENDA team
Kowalewski, M.P.; Mason, J.I.; Howie, A.F.; Morley, S.D.; Schuler, G.; Hoffmann, B.
Characterization of the canine 3beta-hydroxysteroid dehydrogenase and its expression in the corpus luteum during diestrus
J. Steroid Biochem. Mol. Biol.
101
254-262
2006
Canis lupus familiaris
Manually annotated by BRENDA team
Pletnev, V.Z.; Thomas, J.L.; Rhaney, F.L.; Holt, L.S.; Scaccia, L.A.; Umland, T.C.; Duax, W.L.
Rational proteomics V: structure-based mutagenesis has revealed key residues responsible for substrate recognition and catalysis by the dehydrogenase and isomerase activities in human 3beta-hydroxysteroid dehydrogenase/isomerase type 1
J. Steroid Biochem. Mol. Biol.
101
50-60
2006
Homo sapiens (P14060), Homo sapiens
Manually annotated by BRENDA team
Lacey, M.; Bohday, J.; Fonseka, S.M.; Ullah, A.I.; Whitehead, S.A.
Dose-response effects of phytoestrogens on the activity and expression of 3beta-hydroxysteroid dehydrogenase and aromatase in human granulosa-luteal cells
J. Steroid Biochem. Mol. Biol.
96
279-286
2005
Homo sapiens
Manually annotated by BRENDA team
Durocher, F.; Sanchez, R.; Ricketts, M.L.; Labrie, Y.; Laudet, V.; Simard, J.
Characterization of the guinea pig 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase expressed in the adrenal gland and gonads
J. Steroid Biochem. Mol. Biol.
97
289-298
2005
Cavia porcellus
Manually annotated by BRENDA team
Meffre, D.; Delespierre, B.; Gouezou, M.; Schumacher, M.; Stein, D.G.; Guennoun, R.
3beta-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: effect of pseudopregnancy and traumatic brain injury
J. Steroid Biochem. Mol. Biol.
104
293-300
2007
Rattus norvegicus (P22071)
Manually annotated by BRENDA team
Nicolau-Solano, S.I.; Whittington, F.M.; Wood, J.D.; Doran, O.
Relationship between carcass weight, adipose tissue androstenone level and expression of the hepatic 3beta -hydroxysteroid dehydrogenase in entire commercial pigs
Animal
1
1053-1059
2007
Sus scrofa
Manually annotated by BRENDA team
Matsunaga, T.; Endo, S.; Maeda, S.; Ishikura, S.; Tajima, K.; Tanaka, N.; Nakamura, K.T.; Imamura, Y.; Hara, A.
Characterization of human DHRS4: An inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity
Arch. Biochem. Biophys.
477
339-347
2008
Homo sapiens
Manually annotated by BRENDA team
Yang, X.; Dubnau, E.; Smith, I.; Sampson, N.S.
Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase
Biochemistry
46
9058-9067
2007
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Yarim, M.; Karahan, S.; Kabakci, N.; Atmaca, T.
Immunolocalization of 3beta-hydroxysteroid dehydrogenase in normal and hyperplastic ram prostates
Domest. Anim. Endocrinol.
30
17-27
2006
Ovis aries
Manually annotated by BRENDA team
Knapczyk, K.; Duda, M.; Czaplicki, D.; Slomczynska, M.
The presence of 3beta-hydroxysteroid dehydrogenase in the ovarian follicles and corpora lutea of pregnant swine
Exp. Clin. Endocrinol. Diabetes
115
411-416
2007
Sus scrofa
Manually annotated by BRENDA team
Welzel, M.; Wuestemann, N.; Simic-Schleicher, G.; Doerr, H.G.; Schulze, E.; Shaikh, G.; Clayton, P.; Groetzinger, J.; Holterhus, P.M.; Riepe, F.G.
Carboxyl-terminal mutations in 3beta-hydroxysteroid dehydrogenase type II cause severe salt-wasting congenital adrenal hyperplasia
J. Clin. Endocrinol. Metab.
93
1418-1425
2008
Homo sapiens
Manually annotated by BRENDA team
Kim, H.H.; Kwak, D.H.; Yon, J.M.; Baek, I.J.; Lee, S.R.; Lee, J.E.; Nahm, S.S.; Jeong, J.H.; Lee, B.J.; Yun, Y.W.; Nam, S.Y.
Differential expression of 3beta-hydroxysteroid dehydrogenase mRNA in rat testes exposed to endocrine disruptors
J. Reprod. Dev.
53
465-471
2007
Rattus norvegicus
Manually annotated by BRENDA team
Malouitre, S.D.; Barker, S.; Puddefoot, J.R.; Jalili, J.; Glover, H.R.; Vinson, G.P.
Regulation of hepatic steroid receptors and enzymes by the 3beta-hydroxysteroid dehydrogenase inhibitor trilostane
J. Steroid Biochem. Mol. Biol.
101
97-105
2006
Rattus norvegicus
Manually annotated by BRENDA team
Thomas, J.L.; Huether, R.; Mack, V.L.; Scaccia, L.A.; Stoner, R.C.; Duax, W.L.
Structure/function of human type 1 3beta-hydroxysteroid dehydrogenase: An intrasubunit disulfide bond in the Rossmann-fold domain and a Cys residue in the active site are critical for substrate and coenzyme utilization
J. Steroid Biochem. Mol. Biol.
107
80-87
2007
Homo sapiens
Manually annotated by BRENDA team
Wang, L.; Salavaggione, E.; Pelleymounter, L.; Eckloff, B.; Wieben, E.; Weinshilboum, R.
Human 3beta-hydroxysteroid dehydrogenase types 1 and 2: Gene sequence variation and functional genomics
J. Steroid Biochem. Mol. Biol.
107
88-99
2007
Homo sapiens
Manually annotated by BRENDA team
Herl, V.; Frankenstein, J.; Meitinger, N.; Mueller-Uri, F.; Kreis, W.
Delta5-3beta-hydroxysteroid dehydrogenase (3betaHSD) from Digitalis lanata. Heterologous expression and characterisation of the recombinant enzyme
Planta Med.
73
704-710
2007
Digitalis lanata (Q93Y47)
Manually annotated by BRENDA team
Szoltys, M.; Slomczynska, M.; Galas, J.; Duda, M.; Sakiewicz, A.
Expression of androgen receptor and 3beta-hydroxysteroid dehydrogenase in corpora lutea during pregnancy in the rat
Reprod. Fertil. Dev.
19
356-365
2007
Rattus norvegicus
Manually annotated by BRENDA team
Thomas, J.L.; Mack, V.L.; Glow, J.A.; Moshkelani, D.; Terrell, J.R.; Bucholtz, K.M.
Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane
J. Steroid Biochem. Mol. Biol.
111
66-73
2008
Homo sapiens
Manually annotated by BRENDA team
Lysiak, J.J.; Kirby, J.L.; Tremblay, J.J.; Woodson, R.I.; Reardon, M.A.; Palmer, L.A.; Turner, T.T.
Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity
J. Androl.
30
146-156
2009
Mus musculus
Manually annotated by BRENDA team
Parthasarathy, C.; Balasubramanian, K.
Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis
J. Cell. Biochem.
104
1671-1683
2008
Rattus norvegicus (P22071)
Manually annotated by BRENDA team
Hu, G.X.; Zhou, H.Y.; Li, X.W.; Chen, B.B.; Xiao, Y.C.; Lian, Q.Q.; Liang, G.; Kim, H.H.; Zheng, Z.Q.; Hardy, D.O.; Ge, R.S.
The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes
J. Steroid Biochem. Mol. Biol.
115
14-19
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Thomas, J.L.; Bucholtz, K.M.; Sun, J.; Mack, V.L.; Kacsoh, B.
Structural basis for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells
Mol. Cell. Endocrinol.
301
174-182
2009
Homo sapiens
Manually annotated by BRENDA team
Fernandez Presas, A.M.; Valdez, R.A.; Willms, K.; Romano, M.C.
The key steroidogenic enzyme 3beta-hydroxysteroid dehydrogenase in Taenia solium and Taenia crassiceps (WFU)
Parasitol. Res.
103
847-852
2008
Taenia crassiceps, Taenia solium, Taenia crassiceps WFU
Manually annotated by BRENDA team
Nittono, H.; Takei, H.; Unno, A.; Shimizu, T.; Kobayashi, M.; Koike, M.; Murai, T.; Kurosawa, T.; Thoma, M.
3?-hydroxy-??-C??-steroid dehydrogenase/isomerase deficiency in a patient who underwent oral bile acid therapy for 10 years and delivered two healthy infants.
Pediatr. Internat.
52
e192-e195
2010
Homo sapiens
Manually annotated by BRENDA team
Ernst, M.; de Padua, R.M.; Herl, V.; Mueller-Uri, F.; Kreis, W.
Expression of 3beta-HSD and P5betaR, genes respectively coding for Delta5-3beta-hydroxysteroid dehydrogenase and progesterone 5beta-reductase, in leaves and cell cultures of Digitalis lanata EHRH
Planta Med.
76
923-927
2010
Digitalis lanata (Q93Y47), Digitalis lanata EHRH (Q93Y47)
Manually annotated by BRENDA team
Owen, R.W.; Mason, A.N.; Bilton, R.F.
The degradation of beta-sitosterol by Pseudomonas sp. NCIB 10590 under aerobic conditions
J. Steroid Biochem.
23
327-332
1985
Pseudomonas sp., Pseudomonas sp. 10590
Manually annotated by BRENDA team
Rajapaksha, M.; Thomas, J.L.; Streeter, M.; Prasad, M.; Whittal, R.M.; Bell, J.D.; Bose, H.S.
Lipid-mediated unfolding of 3beta-hydroxysteroid dehydrogenase 2 is essential for steroidogenic activity
Biochemistry
50
11015-11024
2011
Homo sapiens (P26439)
Manually annotated by BRENDA team
Thomas, S.T.; Yang, X.; Sampson, N.S.
Inhibition of the M. tuberculosis 3beta-hydroxysteroid dehydrogenase by azasteroids
Bioorg. Med. Chem. Lett.
21
2216-2219
2011
Mycobacterium tuberculosis (P9WQP7), Mycobacterium tuberculosis H37Rv (P9WQP7)
Manually annotated by BRENDA team
Pawlak, K.J.; Prasad, M.; Thomas, J.L.; Whittal, R.M.; Bose, H.S.
Inner mitochondrial translocase Tim50 interacts with 3beta-hydroxysteroid dehydrogenase type 2 to regulate adrenal and gonadal steroidogenesis
J. Biol. Chem.
286
39130-39140
2011
Sus scrofa
Manually annotated by BRENDA team
Prasad, M.; Thomas, J.L.; Whittal, R.M.; Bose, H.S.
Mitochondrial 3beta-hydroxysteroid dehydrogenase enzyme activity requires reversible pH-dependent conformational change at the intermembrane space
J. Biol. Chem.
287
9534-9546
2012
Homo sapiens (P26439)
Manually annotated by BRENDA team
Zhao, Y.; Xiao, J.
Homology modeling and molecular dynamics simulation studies of human type 1 3beta-hydroxysteroid dehydrogenase: Toward the understanding of cofactor specificity
J. Comput. Chem.
32
33-42
2011
Homo sapiens (P14060), Homo sapiens
Manually annotated by BRENDA team
Wojciechowicz, B.; Kotwica, G.; Kolakowska, J.; Franczak, A.
The activity and localization of 3beta-hydroxysteroid dehydrogenase/DELTA(5)-DELTA(4) isomerase and release of androstenedione and progesterone by uterine tissues during early pregnancy and the estrous cycle in pigs
J. Reprod. Dev.
59
49-58
2013
Sus scrofa
Manually annotated by BRENDA team
Thomas, J.L.; Mack, V.L.; Sun, J.; Terrell, J.R.; Bucholtz, K.M.
The functions of key residues in the inhibitor, substrate and cofactor sites of human 3beta-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis
J. Steroid Biochem. Mol. Biol.
120
192-199
2010
Homo sapiens (P14060), Homo sapiens (P26439)
Manually annotated by BRENDA team
Nakamura, Y.; Xing, Y.; Hui, X.G.; Kurotaki, Y.; Ono, K.; Cohen, T.; Sasano, H.; Rainey, W.E.
Human adrenal cells that express both 3?-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production
J. Steroid Biochem. Mol. Biol.
123
122-126
2011
Homo sapiens
Manually annotated by BRENDA team
Thomas, J.; Bucholtz, K.; Kacsoh, B.
Selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer
J. Steroid Biochem. Mol. Biol.
125
57-65
2011
Homo sapiens (P14060), Homo sapiens (P26439)
Manually annotated by BRENDA team
Rasmussen, M.; Brunius, C.; Ekstrand, B.; Zamaratskaia, G.
Expression of hepatic 3beta-hydroxysteroid dehydrogenase and sulfotransferase 2A1 in entire and castrated male pigs
Mol. Biol. Rep.
39
7927-32
2012
Sus scrofa (Q9N119)
Manually annotated by BRENDA team
Ryzhavskii, B.Y.; Zadvornaya, O.V.
3beta-hydroxysteroid dehydrogenase in the brain ependymocytes
Bull. Exp. Biol. Med.
155
113-114
2013
Rattus norvegicus
Manually annotated by BRENDA team
Yang, G.; Dou, J.; Zhang, X.; Gu, W.; Lv, Z.; DU, J.; Ba, J.; Mu, Y.; Lu, J.
Increased 3beta-hydroxysteroid dehydrogenase 2 and 17beta-hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report
Exp. Ther. Med.
11
530-534
2016
Homo sapiens
Manually annotated by BRENDA team
Mishra, S.; Chaube, R.
Distribution and localization of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) in the brain and its regions of the catfish Heteropneustes fossilis
Gen. Comp. Endocrinol.
241
80-88
2017
Heteropneustes fossilis
Manually annotated by BRENDA team
Smolinska, N.; Dobrzyn, K.; Kiezun, M.; Szeszko, K.; Maleszka, A.; Kaminski, T.
Effect of adiponectin on the steroidogenic acute regulatory protein, P450 side chain cleavage enzyme and 3beta-hydroxysteroid dehydrogenase gene expression, progesterone and androstenedione production by the porcine uterus during early pregnancy
J. Physiol. Pharmacol.
67
443-456
2016
Sus scrofa
Manually annotated by BRENDA team
Thomas, J.L.; Bose, H.S.
Regulation of human 3-beta-hydroxysteroid dehydrogenase type-2 (3betaHSD2) by molecular chaperones and the mitochondrial environment affects steroidogenesis
J. Steroid Biochem. Mol. Biol.
151
74-84
2015
Homo sapiens
Manually annotated by BRENDA team
Ota, T.; Doi, M.; Yamazaki, F.; Yarimizu, D.; Okada, K.; Murai, I.; Hayashi, H.; Kunisue, S.; Nakagawa, Y.; Okamura, H.
Angiotensin II triggers expression of the adrenal gland zona glomerulosa-specific 3beta-hydroxysteroid dehydrogenase isoenzyme through de novo protein synthesis of the orphan nuclear receptors NGFIB and NURR1
Mol. Cell. Biol.
34
3880-3894
2014
Homo sapiens (P14060), Homo sapiens
Manually annotated by BRENDA team
Yamamura, K.; Doi, M.; Hayashi, H.; Ota, T.; Murai, I.; Hotta, Y.; Komatsu, R.; Okamura, H.
Immunolocalization of murine type VI 3beta-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta
Mol. Cell. Endocrinol.
382
131-138
2014
Mus musculus (O35469), Mus musculus
Manually annotated by BRENDA team
Konosu-Fukaya, S.; Nakamura, Y.; Satoh, F.; Felizola, S.J.; Maekawa, T.; Ono, Y.; Morimoto, R.; Ise, K.; Takeda, K.; Katsu, K.; Fujishima, F.; Kasajima, A.; Watanabe, M.; Arai, Y.; Gomez-Sanchez, E.P.; Gomez-Sanchez, C.E.; Doi, M.; Okamura, H.; Sasano, H.
3beta-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma
Mol. Cell. Endocrinol.
408
205-212
2015
Homo sapiens, Homo sapiens (P26439)
Manually annotated by BRENDA team
Chen, G.; Bai, Y.; Ren, L.; Zhu, D.; Li, Y.; Fang, M.; Al-Kateb, H.; Doran, O.
Metabolism of androstenone, 17beta-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3beta-hydroxysteroid dehydrogenase in this process
PLoS ONE
10
e113194
2015
Sus scrofa
Manually annotated by BRENDA team
Louw-du Toit, R.; Perkins, M.S.; Snoep, J.L.; Storbeck, K.H.; Africander, D.
Fourth-generation progestins inhibit 3beta-hydroxysteroid dehydrogenase type 2 and modulate the biosynthesis of endogenous steroids
PLoS ONE
11
e0164170
2016
Homo sapiens
Manually annotated by BRENDA team
Ando, T.; Nishiyama, T.; Takizawa, I.; Ishizaki, F.; Miyashiro, Y.; Takeda, K.; Hara, N.; Tomita, Y.
Dihydrotestosterone synthesis pathways from inactive androgen 5alpha-androstane-3beta,17beta-diol in prostate cancer cells: Inhibition of intratumoural 3beta-hydroxysteroid dehydrogenase activities by abiraterone
Sci. Rep.
6
32198
2016
Homo sapiens
Manually annotated by BRENDA team
Zhang, S.; Mo, J.; Wang, Y.; Ni, C.; Li, X.; Zhu, Q.; Ge, R.S.
Endocrine disruptors of inhibiting testicular 3beta-hydroxysteroid dehydrogenase
Chem. Biol. Interact.
303
90-97
2019
Homo sapiens (P26439), Homo sapiens
Manually annotated by BRENDA team
Xu, D.; Wu, M.; Li, X.; Xia, M.; Liu, D.; Dai, Y.; Yu, Q.; Wu, B.; Wang, D.
Cloning, prokaryotic expression and function of the Bufo bufo gargarizans 3beta-hydroxysteroid dehydrogenase (3betaHSD) gene
Int. J. Biol. Macromol.
120
673-682
2018
Bufo gargarizans (A0A345GNZ1)
Manually annotated by BRENDA team
Kordus, R.J.; Hossain, A.; Corso, M.C.; Chakraborty, H.; Whitman-Elia, G.F.; LaVoie, H.A.
Cumulus cell pappalysin-1, luteinizing hormone/choriogonadotropin receptor, amphiregulin and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 mRNA levels associate with oocyte developmental competence and embryo outcomes
J. Assist. Reprod. Genet.
36
1457-1469
2019
Homo sapiens (P26439), Homo sapiens
Manually annotated by BRENDA team
Pham, J.H.; Will, C.M.; Mack, V.L.; Halbert, M.; Conner, E.A.; Bucholtz, K.M.; Thomas, J.L.
Structure-function relationships for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 by a novel androgen analog
J. Steroid Biochem. Mol. Biol.
174
257-264
2017
Homo sapiens (P14060), Homo sapiens (P26439)
Manually annotated by BRENDA team
Lee, H.J.; Nakayasu, M.; Akiyama, R.; Kobayashi, M.; Miyachi, H.; Sugimoto, Y.; Umemoto, N.; Saito, K.; Muranaka, T.; Mizutani, M.
Identification of a 3beta-hydroxysteroid dehydrogenase/ 3-ketosteroid reductase involved in alpha-tomatine biosynthesis in tomato
Plant Cell Physiol.
60
1304-1315
2019
Solanum lycopersicum
Manually annotated by BRENDA team
Zhu, Q.; Pan, P.; Chen, X.; Wang, Y.; Zhang, S.; Mo, J.; Li, X.; Ge, R.S.
Human placental 3beta-hydroxysteroid dehydrogenase/steroid ?5,4-isomerase 1 Identity, regulation and environmental inhibitors
Toxicology
425
152253
2019
Homo sapiens (P14060)
Manually annotated by BRENDA team