1.1.1.145: 3beta-hydroxy-DELTA5-steroid dehydrogenase

This is an abbreviated version!
For detailed information about 3beta-hydroxy-DELTA5-steroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.145

1.1.1.145

steroidogenic

adrenal

steroidogenesis

star

cyp11a1

progesterone

androgen

ovary

ovarian

gonad

follicle

granulosa

leydig

cortisol

adrenocortical

dehydroepiandrosterone

aldosterone

androstenedione

aromatase

dheas

21-hydroxylase

hsd17b3

pregnenolone

reticularis

srd5a2

lhcgr

nci-h295r

p450scc

cyp21

genitalia

hyperandrogenism

akr1c3

p450arom

adrenarche

hypospadias

17-hydroxypregnenolone

17-hydroxyprogesterone

pubarche

steroidogenesis-related

aldosterone-producing

salt-wasting

17alpha-hydroxylase

sult2a1

virilization

medicine

diagnostics

cortisol-producing

nutrition

Reaction

Synonyms

3 beta- and steroid deltaisomerase 1, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-delta(5)-steroid dehydrogenase, 3-beta-hydroxysteroid dehydrogenase, 3-beta-hydroxysteroid dehydrogenase type-2, 3beta hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-HSD type II, 3beta-HSD1, 3beta-HSD2, 3beta-HSD22, 3beta-HSDH, 3beta-HSD_1, 3beta-hydroxy steroid dehydrogenase/5-ene-4-ene isomerase, 3beta-hydroxy steroid dehydrogenase/isomerase, 3beta-hydroxy-5-ene steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid oxidoreductase, 3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase, 3beta-hydroxy-DELTA5-C27-steroid oxidoreductase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase 1, 3beta-hydroxysteroid dehydrogenase 2, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase type 2, 3beta-hydroxysteroid dehydrogenase type 2 and, 3beta-hydroxysteroid dehydrogenase type II, 3beta-hydroxysteroid dehydrogenase type1, 3beta-hydroxysteroid dehydrogenase/3-ketosteroid reductase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELAT4 isomerase type 2, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase type II, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase type 1, 3beta-hydroxysteroid dehydrogenase/steroid DELTA5,4-isomerase, 3betaHSD, 3betaHSD1, 3betaHSD2, 5-ene-3-beta-hydroxysteroid dehydrogenase, 5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase, dehydrogenase, 3beta-hydroxy-DELTA5-steroid, DELTA5-3beta-hydroxysteroid dehydrogenase, DHRS4, HSD2, HSD3B, HSD3B1, HSD3B2, Hsd3b6, HSDB1, HSDH, More, progesterone reductase, Sl3betaHSD1, Solyc01g73640, steroid-DELTA5-3beta-ol dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase/isomerase, type 2 3beta-hydroxysteroid dehydrogenase, type 2 3beta-hydroxysteroid dehydrogenase/isomerase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase

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Results	in table
6	Activating Compound
110	AA Sequence
11	Application
1	CAS Registry Number
42	Cloned(Commentary)
77	Cofactor
1	Crystallization (Commentary)
445	Disease/ Diagnostics
9	Expression
11	General Information
30	IC50 Value
166	Inhibitors
48	kcat/KM [mM/s]
57	Ki Value [mM]
262	KM Value [mM]
40	Localization
1	Metals/Ions
18	Molecular Weight [Da]
93	Natural Substrates/ Products (Substrates)
125	Organism
15	Pathway
4	PDB ID
19	pH Optimum
7	pH Range
2	pH Stability
1	pI Value
73	Protein Variants
25	Purification (Commentary)
6	Reaction
3	Reaction Type
119	Reference
2	Renatured (Commentary)
175	Source Tissue
26	Specific Activity [micromol/min/mg]
2	Storage Stability
299	Substrates and Products (Substrate)
14	Subunits
136	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
3	Temperature Range [°C]
8	Temperature Stability [°C]
139	Turnover Number [1/s]

Purification

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Purification on EC 1.1.1.145 - 3beta-hydroxy-DELTA5-steroid dehydrogenase

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8 entries

native enzyme to homogeneity by streptomycin and ammonium sulfate precipitation, ion exchange chromatography, gel filtration, and affinity chromatography on an NAD+-linked resin, thereby separation from 3alpha-hydroxysteroid dehydrogenase, EC 1.1.1.50

Pseudomonas sp.

389370

partial

Streptomyces griseocarneus

389381

purification of the chimeric S194G-1 mutant of the enzyme (3beta-HSD1)

Homo sapiens

P14060, P26439

763397

purified from Sf9 cells in the presence of the low-CMC detergent, Igepal CO 720, using a DEAE ion exchange column

Homo sapiens

P26439

725511

recombinant 3beta-HSD

Homo sapiens

655345, 656788

recombinant 3beta-HSD type 2

Homo sapiens

655345, 656788

recombinant 3beta-HSD1

2 entries

recombinant protein

2 entries

recombinant soluble wild-type and mutant isozyme 3beta-HSD1 from Sf9 insect cells

Homo sapiens

P14060, P26439

662371

recombinant soluble wild-type and mutant isozyme 3beta-HSD2 from Sf9 insect cells

Homo sapiens

P14060, P26439

662371