1.1.1.141: 15-hydroxyprostaglandin dehydrogenase (NAD+)

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For detailed information about 15-hydroxyprostaglandin dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.141

1.1.1.141

cox-2

cyclooxygenase-2

fetal

arachidonic

pregnancy

chorion

labor

pgf2alpha

indomethacin

parturition

nsaid

trophoblast

preterm

myometrium

chemoprevention

15-keto

eicosanoids

thromboxane

prostanoids

decidua

synthase-1

nadp-linked

15-keto-pge2

clubbing

cesarean

osteoarthropathy

prostacyclin

amnion

beta-hydroxysteroid

lipoxins

calcitriol

9-ketoreductase

medicine

slco2a1

6-keto-pgf1

drug development

Reaction

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate

Synonyms

11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase, 15-hydroxy prostaglandin dehydrogenase, 15-hydroxy-prostaglandin-dehydrogenase, 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostaglandin-dehydrogenase, 15-hydroxyprostanoic dehydrogenase, 15-OH-PGDH, 15-PGDH, 15-prostaglandin dehydrogenase, dehydrogenase, 15-hydroxyprostaglandin, HPGD, NAD+ dependent 15-hydroxyprostaglandin dehydrogenase, NAD+ dependent PGDH, NAD+-15-hydroxy prostanoate oxidoreductase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I), NAD+-dependent 15-PGDH, NAD+-linked 15-hydroxyprostaglandin dehydrogenase, NAD-dependent 15-hydroxyprostaglandin dehydrogenase, NAD-specific 15-hydroxyprostaglandin dehydrogenase, nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase, PGDH, prostaglandin dehydrogenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+)

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Results	in table
30	Activating Compound
43	AA Sequence
9	Application
1	CAS Registry Number
23	Cloned(Commentary)
62	Cofactor
1	Crystallization (Commentary)
1263	Disease/ Diagnostics
11	Expression
9	General Information
7	General Stability
108	IC50 Value
268	Inhibitors
7	kcat/KM [mM/s]
38	Ki Value [mM]
100	KM Value [mM]
8	Localization
19	Molecular Weight [Da]
51	Natural Substrates/ Products (Substrates)
164	Organism
6	Pathway
1	PDB ID
19	pH Optimum
2	pH Range
70	Protein Variants
34	Purification (Commentary)
9	Reaction
3	Reaction Type
101	Reference
226	Source Tissue
24	Specific Activity [micromol/min/mg]
8	Storage Stability
175	Substrates and Products (Substrate)
14	Subunits
121	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
4	Temperature Stability [°C]
25	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 1.1.1.141 - 15-hydroxyprostaglandin dehydrogenase (NAD+)

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0.000077

Oryctolagus cuniculus

enzyme activity in kidney cortex

0.00083

recombinant 15-PGDH

0.0014

enzyme from lung

0.0098

enzyme from kidney cortex

285913

0.025

Gallus gallus

enzyme from heart, substrate prostaglandin E2

285912

0.136

Platyrrhini

enzyme from brain, substrate prostaglandin E2

1.75

1.765

1.791

12.15

enzyme from placenta

13.2

assay at 37°C

19.8

recombinant enzyme

enzyme from placenta

6.4

7.79

purified native enzyme

285932

Bos taurus

enzyme from lung

285917

additional information

6 entries