1.1.1.140: sorbitol-6-phosphate 2-dehydrogenase
This is an abbreviated version!
For detailed information about sorbitol-6-phosphate 2-dehydrogenase, go to the full flat file.
Reaction
Synonyms
D-glucitol-6-phosphate dehydrogenase, D-sorbitol-6-phosphate 2-dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, dehydrogenase, D-sorbitol 6-phosphate, Glucitol-6-phosphate dehydrogenase, GutF, GutM, GutR, HmSorD, ketosephosphate reductase, MdS6PDH, More, operon gutFRMCBA, S6PDH, sorbitol-6-P-dehydrogenase, sorbitol-6-phosphate dehydrogenase, SrlD, Stl6PDH
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Inhibitors
Inhibitors on EC 1.1.1.140 - sorbitol-6-phosphate 2-dehydrogenase
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3-(5-((E)-[3,5-bis(methoxycarbonyl)phenyl]diazenyl)-2-hydroxyphenyl)propanoic acid
enzyme inhibition is accompanied by a decrease in total prostaglandin F2alpha
5-phospho-D-arabinonohydroxamic acid
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substrate analogue inhibitor, IC50: 0.040 mM
disodium 4-(5-[(Z)-(4-oxido-2-oxo-1,3-thiazol-5(2H)-ylidene)methyl]furan-2-yl)benzoate
reduces deactivated prostaglandin F2alpha metabolite production in outer root sheath keratinocyte supernatant
ethyl 3-(5-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]furan-2-yl)benzoate
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conversion of D-sorbitol 6-phosphate into D-fructose 6-phosphate is not inhibited by D-mannose 6-phosphate at inhibitor concentrations as high as 10 mM. Conversion of D-fructose 6-phosphate into D-sorbitol 6-phosphate is not observed with concentrations of D-mannose 6-phosphate as high as 5 mM
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additional information
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conversion of D-sorbitol 6-phosphate into D-fructose 6-phosphate is not inhibited by D-mannose 6-phosphate at inhibitor concentrations as high as 10 mM. Conversion of D-fructose 6-phosphate into D-sorbitol 6-phosphate is not observed with concentrations of D-mannose 6-phosphate as high as 5 mM
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