1.1.1.122: D-threo-aldose 1-dehydrogenase

This is an abbreviated version!
For detailed information about D-threo-aldose 1-dehydrogenase, go to the full flat file.

Reaction

Synonyms

(2S,3R)-aldose dehydrogenase, FDH, L-fucose (D-arabinose) dehydrogenase, L-fucose dehydrogenase, Sso1300

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.122 D-threo-aldose 1-dehydrogenase

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Results	in table
6	Activating Compound
1065	AA Sequence
5	Application
1	CAS Registry Number
3	Cloned(Commentary)
15	Cofactor
1	Crystallization (Commentary)
5	General Stability
31	Inhibitors
37	KM Value [mM]
2	Metals/Ions
16	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
22	Organism
5	Pathway
8	pH Optimum
1	pH Range
4	pH Stability
10	Purification (Commentary)
1	Reaction
3	Reaction Type
20	Reference
9	Source Tissue
8	Specific Activity [micromol/min/mg]
6	Storage Stability
59	Substrates and Products (Substrate)
11	Subunits
12	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
12	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 1.1.1.122 - D-threo-aldose 1-dehydrogenase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

3-Amino-3-deoxy-D-arabinose

Sus scrofa

-

-

285806

ADP

Ovis aries aries

-

slight inhibition

285803

Ag+

Acinetobacter sp.

-

complete inhibition at 1 mM

741316

ATP

Ovis aries aries

-

slight inhibition

285803

Cd2+

Oryctolagus cuniculus

-

inhibitory

285805

Co2+

Acinetobacter sp.

-

complete inhibition at 1 mM

741316

Cu2+

3 entries

D-arabinose

Sus scrofa

-

competitive inhibition of L-fucose oxidation at 2.5 mM

285806

D-galactose

Trinickia caryophylli

-

79% inhibition of L-glucose oxidation

285802

D-glucose

Trinickia caryophylli

-

competitive inhibition of L-glucose oxidation, Ki: 130 mM

285802

EDTA

Acinetobacter sp.

-

-

741316

heavy metal ions

Aureobasidium pullulans

-

strong inhibition

285801

-

Hg2+

4 entries

iodoacetic acid

Oryctolagus cuniculus

-

10% inhibition at 1 mM

285805

L-arabinose

Trinickia caryophylli

-

74% inhibition of L-glucose oxidation

285802

L-rhamnose

Trinickia caryophylli

-

74% inhibition of L-glucose oxidation

285802

N-ethylmaleimide

2 entries

NADH

Ovis aries aries

-

Ki: 0.04 mM

285803

p-chloromercuribenzoate

3 entries

p-hydroxymercuribenzoate

Sus scrofa

-

20% loss of activity, saturated

285806

sodium iodoacetate

Sus scrofa

-

20% loss of activity at 20 mM, pH 8.0

285806

thiol reagents

Aureobasidium pullulans

-

strong inhibition

285801

Zn2+

Agrobacterium tumefaciens

-

40% inhibition

285798

Cu2+

Acinetobacter sp.

-

complete inhibition at 1 mM

741316

Cu2+

Agrobacterium tumefaciens

-

80% inhibition

285798

Cu2+

Agrobacterium tumefaciens

-

complete inhibition at 1 mM

285800

Hg2+

Acinetobacter sp.

-

complete inhibition at 1 mM

741316

Hg2+

Agrobacterium tumefaciens

-

complete inhibition

285798

Hg2+

Agrobacterium tumefaciens

-

complete inhibition at 1 mM

285800

Hg2+

Oryctolagus cuniculus

-

-

285805

N-ethylmaleimide

Acinetobacter sp.

-

-

741316

N-ethylmaleimide

Agrobacterium tumefaciens

-

strong inhibition at 0.1 mM

285800

p-chloromercuribenzoate

Agrobacterium tumefaciens

-

90% inhibition

285798

p-chloromercuribenzoate

Agrobacterium tumefaciens

-

strong inhibition at 0.1 mM

285800

p-chloromercuribenzoate

Oryctolagus cuniculus

-

48% inhibition at 1 mM

285805