1.1.1.106: pantoate 4-dehydrogenase

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For detailed information about pantoate 4-dehydrogenase, go to the full flat file.

Reaction

Synonyms

D-pantoate:NAD+ 4-oxidoreductase, pantoate dehydrogenase, pantothenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.106 pantoate 4-dehydrogenase

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Results	in table
1	CAS Registry Number
3	Cofactor
1	General Stability
4	Inhibitors
3	KM Value [mM]
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
7	Organism
1	Pathway
1	pH Range
3	Purification (Commentary)
1	Reaction
3	Reaction Type
5	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
6	Substrates and Products (Substrate)
2	Subunits
3	Synonyms
1	Systematic Name

Inhibitors

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Inhibitors on EC 1.1.1.106 - pantoate 4-dehydrogenase

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5,5'-dithiobis(2-nitrobenzoic acid)

Pseudomonas fluorescens

1 mM, 50% inhibition after 4.6 min, half-inactivation time increases to 7.0 min in the presence of 20 mM D-pantoate

285729

iodacetic acid

Pseudomonas fluorescens

1 mM, 50% inhibition after 14 min, half-inactivation time increases to 29.0 min in the presence of 20 mM D-pantoate, 70% inhibition within 50 min at pH 7.2, 20 mM pantoate decreases inactivation from 70 to 30%

285729

p-chloromercuribenzoate

Pseudomonas fluorescens

0.1 mM, 85% inhibition after 15 min, 200 mM 2-mercaptoethanol restores 70% of enzyme activity within 10 min, 20 mM D-pantoate and 1 mM NAD+ prevent inactivation when added simultaneously

285729

Phenylglyoxal

Pseudomonas fluorescens

5.3 mM, 70% inhibition in borate buffer, 92% inhibition in NaHCO3 buffer within 10 min, complete inactivation after prolonged incubation with phenylglyoxal, NAD+ and D-pantoate increase half-inactivation time from 6 min without substrates to 40 and 17 min respectively

285729